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Welsh IC, Kwak H, Chen FL, Werner M, Shopland LS, Danko CG, Lis JT, Zhang M, Martin JF, Kurpios NA. (2015) Chromatin Architecture of the Pitx2 Locus Requires CTCF- and Pitx2-Dependent Asymmetry that Mirrors Embryonic Gut Laterality. Cell Rep. 2015 Oct 13;13(2):337-49 **Cover article** PubMed link. The Cell Reports paper is here. Welsh Cover

MahadevanA, Welsh IC, Sivakumar A, Gludish DW, Shilvock AR, Noden DM, Huss D, Lansford R,Kurpios NA (2014) The left-right pitx2 pathway drives organ-specific arterial and lymphatic development in the intestine. Dev Cell. 2014 Dec 22;31(6):690-706. **Cover article** PubMed link. The DevCell paper is here.

In this article, we describe a dual origin of gut lymphatics in avian and mammalian embryos. We find that Pitx2 drives an organ-specific patterning program sufficient to induce arteriogenesis and lymphangiognesis on the left side of the devloping gut. Our results suggest a non-venous origin of gut lymphatic vasculature in the dorsal mesentery of the vertebrate intestine. Read more about the article here.

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Welsh IC, Thomsen M, Gludish DW, Alfonso-Parra C, Bai Y, Martin JF, Kurpios NA (2013) Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Dev Cell. Sep 30;26(6):629-44. **Cover article** PubMed link.

Preview commentary: Klezovitch O, Vasioukhin V. (2013) Your gut is right to turn left. Dev Cell. Sep 30;26(6):553-4
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Kurpios NA, Girgis-Gabardo A, Hallett RM, Rogers S, Gludish DW, Kockeritz L, Woodgett J, Cardiff R, Hassell JA. (2013) Single unpurified breast tumor-initiating cells from multiple mouse models efficiently elicit tumors in immune-competent hosts. PLoS One. 8(3):e58151  
   
Savin T*, Kurpios NA*, Shyer AE*, Florescu P, Liang H, Mahadevan L, and Tabin CJ. (2011) On the growth and form of the gut. Nature. Aug 3;476(7358):57-62  
   
Kurpios, N.A., MacNeil, L., Shepherd, T.G., Gludish, D.W., Giacomelli, A.O., and Hassell, J.A. (2009) The Pea3 Ets transcription factor regulates differentiation of multipotent progenitor cells during mammary gland development. Dev. Biol. 325(1):106-121  
   
Kurpios, N.A.*, Ibañes, M.*, Davis, N.M., Lui, W., Katz, T., Martin, J.F., Izpisúa Belmonte, J.C., and Tabin, C.J. (2008) The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion. Proc. Natl. Acad. Sci. USA 105(25):8499-8506. **Cover article** PNAS cover
Davis, N.M, Kurpios, N.A., Sun, X, Gros, J, Martin, J.F, and Tabin, C.J. (2008) The chirality of gut rotation derives from left-right asymmetric changes in the architecture of the dorsal mesentery. Dev. Cell 15(1):134-145.  
   
Youn, B.S., Sen, A., Kallos, M.S., Behie, L.A., Girgis-Gabardo, A., Kurpios, N., Barcelon, M., and Hassell, J.A. (2005) Large-scale expansion of mammary epithelial stem cell aggregates in suspension bioreactors. Biotechnol. Prog. 21(3):984-993.  
   
Chen, C., Ouyang, W., Grigura, V., Zhou, Q., Carnes, K., Lim, H., Zhao, G.Q., Arber, S., Kurpios, N., Murphy, T.L., Cheng, A.M., Hassell, J.A., Chandrashekar, V., Hofmann, M.C., Hess, R.A., and Murphy, K.M. (2005) ERM is required for transcriptional control of the spermatogonial stem cell niche. Nature 436(7053):1030-1034.  
   
Hesselbrock, D.R., Kurpios N., Hassell, J.A., Watson, M.A., and Fleming, T.P. (2005) PEA3, AP-1, and unique repetitive sequence all are involved in transcriptional regulation of the breast cancer-associated gene, mammaglobin. Breast Cancer Res. Treat. 89(3):289-296.  
   
White, D.E., Kurpios, N.A., Zuo, D., Hassell, J.A., Blaess, S., Mueller, U., and Muller, W.J. (2004) Targeted disruption of beta-1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 6(2):159-170.  
   
Kurpios, N.A., Sabolic, N.S., Shepherd, T.G., Fidalgo, G.M., and Hassell, J.A. (2003) Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis. J. Mam. Gland Biol. Neoplasia. 8(2):177-190.  
   
Crawford, H.C., Fingleton, B., Gustavson, M.D., Kurpios, N., Wagenaar, R.A., Hassell J.A., and Matrisian L.M. (2001) The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin/LEF-1 to activate matrilysin transcription in intestinal tumours. Mol. Cell Biol. 21(4):1370-1383.